Rhesus IL17 / IL17a recombinant protein

Rhesus IL17 / IL17a recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

CTLA8; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 8; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 8; IL-17; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED SERINE ESTERASE 8; INTERLEUKIN-17A; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 8. INTERLEUKIN-17A; INTERLEUKIN 17 (CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED SERINE ESTERASE 8); IL17; IL-17A; CTLA-8

F6T3G5

Baculovirus-Insect Cells

A DNA sequence encoding the rhesus IL17A (XP_001106391.1) (Met1-Ala155) was expressed.

Rhesus

The recombinant rhesus IL17A consists of 132 amino acids and predicts a molecular mass of 15.1 kDa.

> 95 % as determined by SDS-PAGE.