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IL-17 antibody

Cat.#: 107382

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Special Price 239.0 USD

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Product Information

  • Product Name
    IL-17 antibody
  • Documents
  • Description
    IL-17 Mouse Monoclonal antibody. Positive FC detected in Jurkat cells. Positive WB detected in U-937 cells, Jurkat cells, Raji cells. Observed molecular weight by Western-blot: 18 kDa
  • Tested applications
    ELISA, WB, FC
  • Species reactivity
    Human, Rat; other species not tested.
  • Alternative names
    CTLA 8 antibody; CTLA8 antibody; IL 17 antibody; IL 17A antibody; IL17 antibody; IL-17 antibody; IL17A antibody; interleukin 17A antibody
  • Isotype
    Mouse IgG1
  • Preparation
    This antibody was obtained by immunization of IL-17 recombinant protein (Accession Number: NM_002190). Purification method: Protein G purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

  • Validations

    U-937 cells were subjected to SDS PAGE followed by western blot with Catalog No:107382(IL17A antibody) at dilution of 1:500

    U-937 cells were subjected to SDS PAGE followed by western blot with Catalog No:107382(IL17A antibody) at dilution of 1:500

    1X10^6 Jurkat cells were stained with 0.2ug IL17A antibody (Catalog No:107382, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L) with dilution 1:1000.

    1X10^6 Jurkat cells were stained with 0.2ug IL17A antibody (Catalog No:107382, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L) with dilution 1:1000.

  • Background
    IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"