Anti-IL17 / IL17a antibody

Anti-IL17 / IL17a antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse monoclonal to IL17 / IL17a

B/N

Human IL17 / IL17a
Has cross-reactivity with Canine IL17A (500487)
No cross-reactivity with mIL17A (503385) in ELISA assay

CTLA8 antibody; Ctla8 antibody; Ctla-8 antibody; CTLA-8 antibody; cytotoxic T-lymphocyte-associated antigen 8 antibody; cytotoxic T-lymphocyte-associated antigen 8. interleukin-17A antibody; cytotoxic T-lymphocyte-associated protein 8 antibody; cytotoxic T-lymphocyte-associated serine esterase 8 antibody; IL17 antibody; Il17 antibody; IL-17 antibody; IL-17 antibody; IL-17A antibody; IL-17A antibody; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) antibody; interleukin-17A antibody; IL17 antibody; CTLA8 antibody; IL-17 antibody; IL-17A antibody; Il17 antibody; Ctla8 antibody; IL-17 antibody; Ctla-8 antibody; IL-17A antibody

Mouse IgG1

This antibody was obtained from a mouse immunized with purified, recombinant Human IL17 / IL17a (rHuman IL17 / IL17a; Q16552; Ile20-Ala155) and was produced using recombinant antibody technology.

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Block - This IL17a Neutralizing Antibody can block the binding of recombinant IL7a to its recombinant receptor IL17Ra.
Neutralization - The neutralization activity of IL17a Neutralizing Antibody is measured by its ability to neutralize IL6 secretion induced by human IL17a in the HFF human foreskin fibroblast. The Neutralization Titer (IC50) is typically 0.23-0.94 µg/mL in the presence of 50 ng/mL Recombinant Human IL17a.

IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

• Andoh A, et al. (2002) IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. J Immunol. 169(4):1683-7.
• Kotake S, et al. (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 103(9):1345-52.
• Laan M, et al. (1999) Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol. 162(4):2347-52.
• Shin HC, et al. (1999) Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine. 10(11):841-50.