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Product Name
Rhesus gp130/CD130 (His Tag) recombinant protein
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Description
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
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Protein name
Interleukin-6 receptor subunit beta
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Protein short names
IL-6RB; BB405851; IL6R-BETA; D13ERTD699E; 5133400A03RIK; GP130; AA389424; CD130; GP130-RAPS; CDW130; IL6ST
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Uniprot ID
F7FXC5
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Gene Name
IL6ST; EGK_16499
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rhesus IL6ST (NP_001252920.1) (Met1-Ile681) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Rhesus
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Molecular weight
The recombinant rhesus IL6ST comprises 607 amino acids and has a calculated molecular mass of 69.2 KDa.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Cynomolgus IL6ST / gp130 Protein (His Tag) SDS-PAGE
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