Rat KIM-1/TIM1/HACVR1 (His & Fc Tag) recombinant protein

Cat.#: 503461

Size:

Special Price 621.5 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Rat KIM-1/TIM1/HACVR1 (His & Fc Tag) recombinant protein
  • Documents
  • Description
    Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â…  integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
  • Protein name
    Hepatitis A virus cellular receptor 1 homolog
  • Protein short names
    KIM1; HAVCR1; RP23-31K14.2; TIM-1; TIMD1; HAVCR-1; TIM; KIM-1; CANIS LUPUS FAMILIARIS; AI503787; TIMD-1; TIM1; HAVCR
  • Uniprot ID
    O54947
  • Gene Name
    Havcr1; Kim1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of rat HAVCR1 (NP_775172.1) (Ser 18-Val 238) was fused with a polyhistidine tag at the C-terminus and the Fc region of human IgG1 at the N-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat HAVCR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 468 amino acids and predicts a molecular mass of 52.6 kDa. As a result of glycosylation, the apparent molecular mass of the rat HAVCR1/Fc monomer is approximately 90-100 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 93 % as determined by SDS-PAGE
  • Validations

    Rat KIM-1 / TIM1 / HACVR1 Protein (His & Fc Tag) SDS-PAGE

    Rat KIM-1 / TIM1 / HACVR1 Protein (His & Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"