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Product Name
Mouse KIM-1/TIM1/HACVR1 (His & Fc Tag) recombinant protein
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Description
Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
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Protein name
Hepatitis A virus cellular receptor 1 homolog
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Protein short names
KIM1; HAVCR1; RP23-31K14.2; TIM-1; TIM; TIMD1; HAVCR-1; AI503787; CANIS LUPUS FAMILIARIS; KIM-1; TIMD-1; TIM1; HAVCR
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Uniprot ID
Q5QNS5
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Gene Name
Havcr1; mCG_117142
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse HAVCR1 isoform b (NP_001160104.1) (Tyr 22-Thr 212) was fused with a polyhistidine tag at the C-terminus and the Fc region of human IgG1 at the N-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse HAVCR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 438 amino acids and predicts a molecular mass of 49 kDa. As a result of glycosylation, the apparent molecular mass of HAVCR1/Fc monomer is approximately 80-85 kDa in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Mouse KIM-1 / TIM1 / HAVCR1 Protein (His & Fc Tag) SDS-PAGE
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