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Product Name
Human KIM-1/TIM1/HACVR1 (His Tag) recombinant protein
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Description
Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
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Protein name
Hepatitis A virus cellular receptor 1
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Protein short names
TIM; HAVCR-1; TIMD1; TIM-1; RP23-31K14.2; HAVCR1; KIM1; HAVCR; TIM1; TIMD-1; AI503787; CANIS LUPUS FAMILIARIS; KIM-1
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Uniprot ID
Q96D42
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Gene Name
HAVCR1; KIM1; TIM1; TIMD1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human KIM1 extracellular domain (AAC39862.1) (Ser 21-Gly 290) was fused with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The secreted recombinant human KIM1 comprises 289 amino acids and predicts a molecular mass of 31.3 kDa. The apparent molecular mass of the recombinant protein is approximately 80-100 kDa in SDS-PAGE under reducing conditions due to high glycosylation.
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Purity
> 93 % as determined by SDS-PAGE
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Validations
Human KIM-1 / TIM1 / HACVR1 Protein (His Tag) SDS-PAGE
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