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Product Name
Rat Il2/Il-2 (His tag) recombinant protein
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Description
Interleukin-2(IL-2)is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. Mature rat IL-2 shares 66% and 73% amino acid sequence identity with human and mouse IL-2,respectively. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.
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Protein name
interleukin 2(Il2)
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Protein short names
Il-2
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Uniprot ID
P17108
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Rat Il2/Il-2 Ala21-Gln155 is expressed with a 6His tag at the C-terminus.
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Protein Species
Rat
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Purity
>95% as determined by SDS-PAGE.
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Validations
Rat Il2/Il-2 (His tag) recombinant protein
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