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Product Name
Rat CTLA-4/CD152 (Fc Tag) recombinant protein
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Description
Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).
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Protein name
Cytotoxic T-lymphocyte associated protein-4
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Protein short names
CH29-120A16.2; ICOS; ALPS5; CTLA4; CD; LY-56; CTLA-4; CD152; CELIAC3; GRD4; GSE; IDDM12
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Uniprot ID
Q62859
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Gene Name
Ctla4; CTLA-4
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat Ctla4 (NP_113862.1) (Met1-Asp161) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat Ctla4 consists 364 amino acids and predicts a molecular mass of 40.5 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Ctla4 protein SDS-PAGE
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