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Product Name
Mouse CTLA-4/CD152 (Fc Tag) recombinant protein
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Description
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (By similarity).
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Protein name
Cytotoxic T-lymphocyte protein 4
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Protein short names
GSE; IDDM12; CTLA-4; CD152; CELIAC3; GRD4; CTLA4; CD; LY-56; CH29-120A16.2; ICOS; ALPS5
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Uniprot ID
Q6GTR6
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Gene Name
Ctla4; Cd152
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse CTLA4 (NP_033973.2) (Met 1-Phe 162) was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse CTLA4/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 368 amino acids and has a predicted molecular mass of 41 kDa. As a result of glycosylation, the apparent molecular mass of rm CTLA4/Fc monomer is approximately 55 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Mouse CTLA4 / CD152 Protein (Fc Tag) SDS-PAGE
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