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Product Name
Human CTLA-4/CD152 (His & Fc Tag) recombinant protein
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Description
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
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Protein name
Cytotoxic T-lymphocyte protein 4
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Protein short names
CH29-120A16.2; ICOS; ALPS5; CTLA4; CD; LY-56; CTLA-4; CD152; CELIAC3; GRD4; IDDM12; GSE
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Uniprot ID
P16410
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Gene Name
CTLA4; CD152
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CTLA4 (NP_005205.2) extracellular domain (Met 1-Phe 162) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CTLA4/Fc is a disulfide-linked homodimer. The reduced monomer consists of 374 amino acids and has a predicted molecular mass of 41.6 kDa. As a result of glycosylation, the apparent molecular mass of rh CTLA4/Fc monomer is approximately 50-55 kDa in SDS-PAGE under reducing conditions.
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Purity
> 92 % as determined by SDS-PAGE
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Validations
Human CTLA4 / CD152 Protein (His & Fc Tag) SDS-PAGE
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