Rat B7-H3/CD276 (Fc Tag) recombinant protein

Rat B7-H3/CD276 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.

CD276 antigen

CD276; AU016588; B7-H3; B7RP-2; PSEC0249; B7H3; 6030411F23RIK; 4IG-B7-H3

Q7TPB4

Cd276; B7h3

Human Cells

A DNA sequence encoding the rat CD276 (Q7TPB4) (Met1-Phe244) was expressed with the Fc region of human IgG1 at the C-terminus.

Rat

The recombinant rat CD276/Fc is a disulfide-linked homodimer. The reduced monomer comprises 457 amino acids and has a predicted molecular mass of 50.6 kDa. The apparent molecular mass of the protein is approximately 61 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 85 % as determined by SDS-PAGE