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Product Name
Human B7-H3/CD276 (Fc Tag) recombinant protein
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Description
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
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Protein name
CD276 antigen
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Protein short names
CD276; B7RP-2; B7-H3; AU016588; B7H3; PSEC0249; 4IG-B7-H3; 6030411F23RIK
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Uniprot ID
Q5ZPR3
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Gene Name
CD276; B7H3; PSEC0249; UNQ309/PRO352
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CD276 (NP_001019907.1) (Met1-Thr461) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CD276 consists 673 amino acids and predicts a molecular mass of 73.4 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
CD276 protein SDS-PAGE
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