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Product Name
Mouse B7-H3/CD276 (His Tag) recombinant protein
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Description
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.
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Protein name
CD276 antigen
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Protein short names
6030411F23RIK; 4IG-B7-H3; B7RP-2; AU016588; B7-H3; B7H3; CD276; PSEC0249
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Uniprot ID
Q8VE98
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Gene Name
Cd276
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse CD276 (NP_598744.1) (Met1-Phe244) was expressed with a C-terminal polyhistidine tag. The purified protein was biotinylated in vitro.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse CD276 comprises 227 amino acids and has a predicted molecular mass of 24.9 kDa. The apparent molecular mass of the protein is approximately 40.9 kDa in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Mouse CD276 / B7-H3 Protein (His Tag), Biotinylated
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