• Human PKM2 (His Tag) recombinant protein

Human PKM2 (His Tag) recombinant protein

Cat.#: 502362

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Product Information

  • Product Name
    Human PKM2 (His Tag) recombinant protein
  • Documents
  • Description
    Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
  • Protein name
    Pyruvate kinase PKM
  • Protein short names
    CTHBP; THBP1; AL024370; AL024424; PK-2; HEL-S-30; MGC3932; OIP3; AA414905; TCB; PKM2; PKM; PK3; PK-3
  • Uniprot ID
    P14618
  • Gene Name
    PKM; OIP3; PK2; PK3; PKM2
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human PKM2 isoform M2 (P14618-1) (Ser 2-Pro 531) was expressed, with a polyhistide tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human PKM2 consisting of 541 amino acids and migrates as an approximately 59 kDa band in SDS-PAGE under reducing conditions as predicted.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    Kinase activity untested
  • Validations

    Human PKM2 / OIP3 Protein (His Tag) SDS-PAGE

    Human PKM2 / OIP3 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"