Cynomolgus IL-1R1/CD121a (Fc Tag) recombinant protein

Cynomolgus IL-1R1/CD121a (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.

Putative uncharacterized protein

IL-IR; CD121 ANTIGEN-LIKE FAMILY MEMBER A; D2S1473; IL1RA; INTERLEUKIN 1 BETA RECEPTOR TYPE 1 SHORT; IL1R-1; IL-1RT-1; IL-1R-ALPHA; IL-1R-1; IL-1RT1; IL-1R1; P80; CD121B; CD121A; IL1R; RATTUS NORVEGICUS

G7NAT4

EGK_05628

Human Cells

A DNA sequence encoding the cynomolgus IL1R1 (G7NAT4) (Met1-Thr332) was expressed with the Fc region of human IgG1 at the C-terminus.

Cynomolgus

The recombinant cynomolgus IL1R1 is a disulfide-linked homodimer. The reduced monomer comprises 553 amino acids and has a calculated molecular mass of 62.9 KDa.The apparent molecular mass of the protein is approximately 73-93 KDa respectively in SDS-PAGE.

> 95 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA. Immobilized human IL1RA (Cat:504137) at 10 μg/ml (100 μl/well) can bind Cynomolgus IL1R1-Fc, The EC₅₀ of Cynomolgus IL1R1-Fc is 0.04-0.08 μg/mL.