Anti-IL-1R1/CD121a antibody

Anti-IL-1R1/CD121a antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to IL-1R1/CD121a

FCM

Rat IL-1R1 / CD121a

Rattus norvegicus antibody; IL-1R-1 antibody; IL-1R-alpha antibody; IL-1RT1 antibody; IL-1RT-1 antibody; interleukin 1 beta receptor type 1 short antibody; CD121A antibody; CD121b antibody; D2S1473 antibody; IL1R antibody; Il1r-1 antibody; IL1RA antibody; IL-iR antibody; CD121 antigen-like family member A antibody; P80 antibody; CD121a antibody; IL1RA antibody; IL-iR antibody; CD121a antibody; CD121b antibody; IL-1R1 antibody; Il1r-1 antibody; P80 antibody; IL1R antibody; CD121A antibody; D2S1473 antibody; IL-1R-alpha antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Rat IL-1R1 / CD121a (rR IL-1R1 / CD121a; NP_037255.3; Met1-Lys352) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.

Monoclonal

Aqueous solution containing 0.5% BSA and 0.09% sodium azide

This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

FCM

Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.

• Dale M, et al. (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177-9.
• Joos L, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.". Thorax 56 (11): 863-6.
• Vigers GP, et al. (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.". Nature 386 (6621): 190-4.