Human IL1R1/IL1R/IL1RA/IL1RT1 (Fc tag) recombinant protein

Human IL1R1/IL1R/IL1RA/IL1RT1 (Fc tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin 1 receptor, type I (IL-1R1) is an interleukin receptor that belongs to the interleukin-1 receptor family. IL-1R1 is an 80 kDa transmembrane protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. This gene along with IL1R2, IL1RL2, and IL1RL1 form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. IL-1R1 is an important mediator involved in many cytokine induced immune and inflammatory responses. It binds to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. The signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. It also binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. An IL1 receptor accessory protein that can heterodimerize with the Type I receptor in the presence of IL1α or IL1β but not IL1ra, was identified. Recombinant IL1 soluble receptor Type I is a potent antagonist of IL1 action.

interleukin 1 receptor type 1(IL1R1)

IL1R; IL1RA; IL1RT1

P14778

Human Cells

A DNA sequence encoding the Human IL1R1/IL1R/IL1RA/IL1RT1 Leu18-Thr332 is expressed fused with a Fc tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.