Mouse IL-1R1/CD121a (His Tag) recombinant protein

Mouse IL-1R1/CD121a (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex (By similarity).

Interleukin-1 receptor type 1

IL-1R-1; IL-1R-ALPHA; IL-1RT1; IL-1R1; P80; CD121B; CD121A; IL1R; RATTUS NORVEGICUS; IL-IR; CD121 ANTIGEN-LIKE FAMILY MEMBER A; D2S1473; INTERLEUKIN 1 BETA RECEPTOR TYPE 1 SHORT; IL1RA; IL1R-1; IL-1RT-1

P13504

Il1r1; Il-1r1; Il1ra

Human Cells

A DNA sequence encoding the mouse IL1R1 (P13504) extracellular domain (Met 1-Lys 338) was expressed, with a C-terminal polyhistidine tag.

Mouse

The secreted recombinant mouse IL1R1 comprises 330 amino acids and has a calculated molecular mass of 38.7 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 55-60 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

1. Measured by its ability to bind mouse IL1B in a functional ELISA.
2. Immobilized mouse IL1A at 10 μg/mL (100 μl/well) can bind mouse IL1R1, The EC₅₀ of mouse IL1R1 is 0.13 μg/mL.