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Product Name
Human IL-1R1/CD121a recombinant protein
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Description
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.
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Protein name
Interleukin-1 receptor type 1
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Protein short names
CD121B; CD121A; IL1R; RATTUS NORVEGICUS; IL-1R-1; IL-1R-ALPHA; IL-1RT1; IL-1R1; P80; IL-1RT-1; IL1RA; IL1R-1; INTERLEUKIN 1 BETA RECEPTOR TYPE 1 SHORT; CD121 ANTIGEN-LIKE FAMILY MEMBER A; IL-IR; D2S1473
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Uniprot ID
P14778
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Gene Name
IL1R1; IL1R; IL1RA; IL1RT1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human IL1R1 (NP_000868.1) (Met1-Thr332) was expressed with five amino acids (DDDDK) at the C-terminus was expressed and purified.
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Protein Species
Human
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Molecular weight
The recombinant human IL1R1 consists of 321 amino acids and predicts a molecular mass of 36.8 KDa. It migrates as an approximately 56 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human IL1R1 / CD121a Protein SDS-PAGE
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