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Product Name
Human PPM1A/PP2CA (His Tag) recombinant protein
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Description
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
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Protein name
Protein phosphatase 1A
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Protein short names
AI427932; 2900017D14RIK; MMPA-2; PPM1A; MPPA-1; FLJ42306; PP2CA; 2310003C21RIK; PP2CALPHA; AU017636; MGC9201; PP2C-ALPHA
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Uniprot ID
P35813
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Gene Name
PPM1A; PPPM1A
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human PPM1A isoform alpha-1 (P35813-1) (Met 1-Trp 382) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human PPM1A consisting of 392 amino acids and has a calculated molecular mass of 43.8 kDa. It migrates as an approximately 47 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Human PPM1A / PP2CA / PP2C-alpha Protein (His Tag) SDS-PAGE
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