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Product Name
Human PPM1A/PPPM1A (His tag) recombinant protein
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Description
Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also, it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition, PPM1A can dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control.
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Protein name
protein phosphatase, Mg2+/Mn2+ dependent 1A(PPM1A)
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Protein short names
PPPM1A
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Uniprot ID
P35813
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human PPM1A/PPPM1A Gly2-Trp382 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human PPM1A/PPPM1A (His tag) recombinant protein
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