Anti-PPM1A antibody

Anti-PPM1A antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Monoclonal to Mouse PPM1A

WB

Mouse PPM1A / PP2CA

2310003C21Rik antibody; 2900017D14Rik antibody; AI427932 antibody; AU017636 antibody; FLJ42306 antibody; MGC9201 antibody; MMPa-2 antibody; MPPa-1 antibody; PP2CA antibody; PP2CA antibody; PP2Calpha antibody; PP2C-alpha antibody; PP2C-ALPHA antibody; Ppm1a antibody; PP2CA antibody; PP2Calpha antibody; PP2C-ALPHA antibody; MMPa-2 antibody; MPPa-1 antibody; PPM1A antibody; AI427932 antibody; AU017636 antibody; 2310003C21Rik antibody; 2900017D14Rik antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PPM1A / PP2CA .

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and MAP kinase kinases. It has also been demonstrated to inhibit the activation of p38 and JNK kinase cascades. PPM1A dephosphorylates and promotes nuclear export of TGFβ-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFβ-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFβ signaling in mammalian cells. It has been demonstrated that PPM1A / PP2CA, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFβ signaling. Overexpression of PPM1A is reported to activate the expression of the tumor suppressor gene TP53 / p53, which leads to cell apoptosis.