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Product Name
Mouse PPM1A/PP2CA (His Tag) recombinant protein
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Description
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
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Protein name
Protein phosphatase 1A
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Protein short names
2900017D14RIK; AI427932; PPM1A; MMPA-2; PP2CA; FLJ42306; MPPA-1; 2310003C21RIK; PP2CALPHA; AU017636; MGC9201; PP2C-ALPHA
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Uniprot ID
Q9EQE3
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Gene Name
Ppm1a; Pppm1a
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse PPM1A (NP_032936.1) (Met 1-Trp 382) was expressed, with a polyhistide tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse PPM1A consisting of 388 amino acids and has a calculated molecular mass of 43.3 kDa as estimated in SDS-PAGE under reducing conditions.
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Purity
> 98 % as determined by SDS-PAGE
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Validations
Mouse PPM1A / PP2CA / PP2C-alpha Protein (His Tag) SDS-PAGE
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