Human PD-L1/B7-H1/CD274 (Fc Tag) recombinant protein

Human PD-L1/B7-H1/CD274 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

Programmed cell death 1 ligand 1

MGC142296; B7-H; CD274 A530045L16RIK; MGC142294; PDL1; PDCD1LG1; PD-L1; CD274; B7H1; PDCD1L1

Q9NZQ7

CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1

Human Cells

A DNA sequence encoding the human CD274 (NP_054862.1) (Met1-Thr239) was expressed with the Fc region of mouse IgG1 at the C-terminus.

Human

The recombinant human CD274 consists of 455 amino acids and predicts a molecular mass of 51.7 kDa.

> 95 % as determined by SDS-PAGE.

Measured by its ability to inhibit anti-CD3 antibody induced IFNγ secretion in human T lymphocytes.
The ED₅₀ for this effect is 2-10 μg/mL.