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Product Name
Rhesus CD155/PVR (His Tag) recombinant protein
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Description
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.
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Protein name
Poliovirus receptor
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Protein short names
HVED; PVS; TAA1; NECL5; NECL-5; D7ERTD458E; 3830421F03RIK; CD155; ME4; TAGE4; PVR
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Uniprot ID
Q0MSE6
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Gene Name
PVR; LOC722351
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rhesus PVR (NP_001036851.1) extracellular domain (Met 1-Asn 343) was expressed with a C-terminal polyhistidine tag.
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Protein Species
Rhesus
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Molecular weight
The recombinant rhesus PVR consists of 327 amino acids and has a calculated molecular mass of 35.8 kDa.
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Purity
> 98 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized Rhesus CD155 at 2 μg/ml (100 μl/well) can bind human CD226 with a linear ranger of 1.28-32 ng/ml.
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Validations
Cynomolgus CD155 / PVR Protein (His Tag) SDS-PAGE
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