Human CD155/PVR (His Tag) recombinant protein

Human CD155/PVR (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

HVED; TAA1; PVS; NECL5; NECL-5; D7ERTD458E; 3830421F03RIK; CD155; ME4; TAGE4; PVR

P15151

Human Cells

A DNA sequence encoding the human CD155 isoform a (NP_006496.3) extracellular domain (Met 1-Asn 343) was fused with a polyhistidine tag at the C-terminus.

Human

The recombinant human CD155 consists of 334 amino acids and has a predicted molecular mass of 36.5 kDa. As a result of glycosylation, the rhCD155/Fc monomer migrates as approximately 60-65 kDa band in SDS-PAGE under reducing conditions.

> 97 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA. Immobilized human CD155 at 2 μg/ml (100 μl/well) can bind human DNAM1 with a linear ranger of 1.28-32 ng/ml.