Mouse CD155/PVR (His Tag) recombinant protein

Mouse CD155/PVR (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

Nectin-2

CD155; 3830421F03RIK; ME4; TAGE4; PVR; HVED; TAA1; PVS; NECL-5; NECL5; D7ERTD458E

Q8K094

Pvr; D7Ertd458e; Tage4; mCG_4885

Human Cells

A DNA sequence encoding the mouse CD155 (NP_081790.1) precursor (Met 1-Arg 345) was expressed with a C-terminal polyhistidine tag.

Mouse

The secreted recombinant mouse CD155 generated after removal of the signal peptide comprises 329 amino acids with a predicted molecular mass of 28 kDa. As a result of glycosylation, it migrates as an approximately 60-65 kDa band in SDS-PAGE under reducing conditions.

> 97 % as determined by SDS-PAGE

Measured by its ability to bind recombinant mouse CD226/DNAM-1.Immobilized recombinant mouse CD155/PVR at 1 μg/ml (100 μl/well) can bind recombinant mouse CD226/DNAM-1 with a linear range of 0.78-100 ng/ml.