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Human IkB alpha/NFKBIA (His Tag) recombinant protein

Cat.#: 500991

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Product Information

  • Product Name
    Human IkB alpha/NFKBIA (His Tag) recombinant protein
  • Documents
  • Description
    Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
  • Protein name
    NF-kappa-B inhibitor alpha
  • Protein short names
    NFKBI; MAD-3; IKBA; IKB ALPHA; NFKBIA; AI462015
  • Uniprot ID
    P25963
  • Gene Name
    NFKBIA; IKBA; MAD3; NFKBI
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human NFKBIA (NP_065390.1) (Phe 2-Leu 317) was expressed, with a polyhistide tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human NFKBIA consisting of 323 amino acids and has a calculated molecular mass of 36.4 kDa. It migrates as an approximately 38 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Human IKB alpha / NFKBIA Protein (His Tag) SDS-PAGE

    Human IKB alpha / NFKBIA Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"