Mouse LAG3 recombinant protein (C-human IgG1-Fc)

Mouse LAG3 recombinant protein (C-human IgG1-Fc)

• DataSheet
• Material Safety Data Sheets (MSDS)

LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.Immune Checkpoint
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Lymphocyte activation gene 3 protein

CD223,LAG-3,Ly66

Q61790

Lymphocyte activation gene 3 protein; LAG-3; CD antigen CD223

Human Cells

A DNA sequence encoding the mouse LAG3 (NP_032505.1) (Met1-Arg432) was expressed with the Fc region of human IgG1 at the C-terminus.

Mouse

The recombinant mouse LAG3 consists of 647 amino acids and predicts a molecular mass of 71 kDa.

> 95 % as determined by SDS-PAGE.