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Product Name
Human LAG3 / CD223 / Lymphocyte activation gene 3 (Fc Tag) recombinant protein
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Description
LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.
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Protein name
Lymphocyte activation gene 3 protein
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Protein short names
LYMPHOCYTE-ACTIVATION GENE 3; LY66; LAG-3; LYMPHOCYTE ACTIVATION GENE 3 PROTEIN; LAG3; CD223
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Uniprot ID
P18627
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Gene Name
LAG3; FDC
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human LAG3 (NP_002277.4) (Met1-Leu450) was expressed with the Fc region of mouse IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human LAG3 consists of 656 amino acids and predicts a molecular mass of 72 kDa.
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Purity
> (81.3+10.1) % as determined by SDS-PAGE.
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Validations
Human LAG3 / CD223 / Lymphocyte activation gene 3 Protein (Fc Tag)
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