Human LAG3 recombinant protein (Native)

Human LAG3 recombinant protein (Native)

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LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.Immune Checkpoint
Immune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy

Lymphocyte activation gene 3 protein

CD223,LAG-3

P18627

Lymphocyte activation gene 3 protein; LAG-3; Protein FDC; CD antigen CD223

Human Cells

A DNA sequence encoding the human LAG3 (P18627) (Met1-Arg440) was expressed with an initial Met.

Human

The recombinant human LAG3 consists of 412 amino acids and predicts a molecular mass of 44.7 kDa.

> 90 % as determined by SDS-PAGE.