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Mouse IL10RB / IL-10RB (Fc Tag) recombinant protein

Cat.#: 503473

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Product Information

  • Product Name
    Mouse IL10RB / IL-10RB (Fc Tag) recombinant protein
  • Documents
  • Description
    Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
  • Protein name
    Interleukin 10 receptor 2
  • Protein short names
    IL-10R2; AI528744; D16H21S58; IL10R2; 6620401D04RIK; CRF2-4; CRFB4; CDW210B; IL10RB; D21S66; D21S58; D21S58H
  • Uniprot ID
    Q8VHM7
  • Gene Name
    Il10rb; Il10r2; mCG_11439
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of mouse IL10RB (NP_032375.2) (Met 1-Ser 222) was fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse IL10RB Fc is a disulfide-linked homodimer. The reduced monomer comprises comprises 442 amino acids and has a calculated molecular mass of 50.5 kDa. As a result of glycosylation, the apparent molecular mass of rm IL10RB/Fc monomer is approximately 65-75 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 92 % as determined by SDS-PAGE
  • Validations

    Mouse IL10RB / IL10R2 Protein (Fc Tag) SDS-PAGE

    Mouse IL10RB / IL10R2 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"