Human IL10RB / IL-10RB (His Tag) recombinant protein

Human IL10RB / IL-10RB (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

Interleukin-10 receptor subunit beta

IL10R2; CRF2-4; CDW210B; CRFB4; 6620401D04RIK; D16H21S58; IL-10R2; AI528744; D21S58H; D21S66; IL10RB; D21S58

Q08334

IL10RB; CRFB4; D21S58; D21S66

Human Cells

A DNA sequence encoding the extracellular domainof human IL10R? (NP_000619.3) (Met 1-Ser 220) was expressed, fused with a polyhistidine tag at the C-terminus.

Human

The recombinant human IL10R? comprises 212 amino acids and has a predicted molecular mass of 25 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhIL10R? is approximately 45-48 kDa due to glycosylation.

> 92 % as determined by SDS-PAGE