Anti-IL10RB / IL-10RB antibody

Anti-IL10RB / IL-10RB antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to IL10RB / IL-10RB

ELISA, WB

Human IL10RB / IL-10RB

6620401D04Rik antibody; AI528744 antibody; CDW210B antibody; CRF2-4 antibody; CRF2-4 antibody; Crfb4 antibody; CRFB4 antibody; D16H21S58 antibody; D21S58 antibody; D21S58h antibody; D21S66 antibody; Il10r2 antibody; IL-10R2 antibody; IL-10R2 antibody; Il10rb antibody; IL10RB antibody; CRFB4 antibody; CRF2-4 antibody; D21S58 antibody; D21S66 antibody; CDW210B antibody; IL-10R2 antibody; Crfb4 antibody; CRF2-4 antibody; Il10r2 antibody; D21S58h antibody; IL-10R2 antibody; AI528744 antibody; D16H21S58 antibody; 6620401D04Rik antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human IL10RB / IL-10RB (rh IL10RB / IL-10RB; NP_000619.3; Met1-Ser220). IL10RB / IL-10RB specific IgG was purified by Human IL10RB / IL-10RB affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

• Josephson K, et al. (2001) Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 15 (1): 35-46.
• Yoo KH, et al. (2011) Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population. J Korean Med Sci. 26(5): 659-64.