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Product Name
Mouse CXADR / CAR (Fc & His Tag) recombinant protein
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Description
CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein belonging to the CTX family of the Ig superfamily, and is essential for normal cardiac development in the mouse. Proposed as a homophilic cell adhesion molecule, CXADR is a component of the epithelial apical junction complex that is essential for the tight junction integrity, and probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN). Mature mouse CXADR structrually comprises a 218 aa extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment and a 107 aa intracellular domain, among which,D1 is thought to be responsible for homodimer formation in trans within tight junctions. The ECD of mouse CXADR shares 97%, 90% sequence identity with the corresponding regions of rat, human CXADR.
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Protein name
Coxsackievirus and adenovirus receptor homolog
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Protein short names
MCVADR; AU016810; 2610206D03RIK; CAR4/6; CXADR; CAR; AW553441; HCAR; MCAR
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Uniprot ID
P97792
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Gene Name
Cxadr; Car
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse Cxadr (NP_001020363.1) (Met1-Gly237) was expressed with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus (Fc-his).
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Protein Species
Mouse
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Molecular weight
The recombinant mouse Cxadr consists of 465 amino acids and predicts a molecular mass of 52 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
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