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Product Name
Mouse CXADR / CAR recombinant protein
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Description
Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
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Protein name
Coxsackievirus and adenovirus receptor homolog
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Protein short names
CXADR; MCAR; HCAR; AW553441; CAR; 2610206D03RIK; AU016810; MCVADR; CAR4/6
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Uniprot ID
P97792
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Gene Name
Cxadr; Car
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse CXADR (NP_001020363.1) (Met 1-Gly 237) was expressed with six amino acids (ENLYFQ) at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse CXADR consists of 225 amino acids and has a calculated molecular mass of 25 kDa. The recombinant protein migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Mouse CXADR / CAR Protein SDS-PAGE
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