Mouse Ctla4/Cd152 (His tag) recombinant protein

Mouse Ctla4/Cd152 (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).

cytotoxic T-lymphocyte-associated protein 4(Ctla4)

Cd152

P09793

Human Cells

A DNA sequence encoding the Mouse Ctla4/Cd152 Ala37-Asp161 is expressed fused with a 6His tag at the C-terminus.

Mouse

>95% as determined by SDS-PAGE.