Mouse LAIR-1 / CD305 (His Tag) recombinant protein

Mouse LAIR-1 / CD305 (His Tag) recombinant protein

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Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity).

Leukocyte-associated immunoglobulin-like receptor 1

LAIR-1; BB115266; XXBAC-BCX403H19.4; 5133400O11RIK; D7BWG0421E; MLAIR-1; CD305

Q8BG84

Lair1

Human Cells

A DNA sequence encoding the mouse LAIR1 (Q8BG84-1) extracellular domain (Gln 22-Ser 133) was expressed, with a C-terminal polyhistidine tag.

Mouse

The secreted recombinant mouse LAIR1 comprises 123 amino acids and has a calculated molecular mass of 14 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 25-35 kDa in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE