Anti-LAIR-1 / CD305 antibody

Cat.#: 106164

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Product Information

  • Product Name
    Anti-LAIR-1 / CD305 antibody
  • Documents
  • Description
    Rabbit polyclonal to LAIR-1 / CD305
  • Tested applications
    ELISA, IHC-P
  • Species reactivity
    Mouse LAIR1
  • Alternative names
    CD305 antibody; LAIR-1 antibody; Lair-1 antibody; BB115266 antibody; D7Bwg0421e antibody; 5133400O11Rik antibody; 5133400O11Rik antibody; BB115266 antibody; CD305 antibody; D7Bwg0421e antibody; Lair-1 antibody; LAIR-1 antibody; mLair-1 antibody; XXbac-BCX403H19.4 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Mouse LAIR1 (rh LAIR1; Q8BG84-1; Gln22-Ser133). LAIR1 specific IgG was purified by Mouse LAIR1 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA:0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse LAIR1. The detection limit for Mouse LAIR1 is < 0.039 ng/well.

    IHC-P: 1-5 μg/ml

  • Validations

    LAIR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    LAIR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    LAIR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    LAIR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

  • Background
    Leukocyte associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and are able to spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells, but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells. 
  • References
    • Meyaard L, et al. (1999) Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. J Immunol. 162 (10): 5800-4.
    • Meyaard L, et al. (2001) The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). J Exp Med. 194 (1): 107-12.
    • Xu M, et al. (2000) Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. J Biol Chem. 275 (23): 17440-6.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"