Human LAIR-1 / CD305 (His Tag) recombinant protein

Cat.#: 503828

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Product Information

  • Product Name
    Human LAIR-1 / CD305 (His Tag) recombinant protein
  • Documents
  • Description
    Leukocyte associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and are able to spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells, but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells. 
  • Protein name
    Leukocyte-associated immunoglobulin-like receptor 1
  • Protein short names
    D7BWG0421E; 5133400O11RIK; BB115266; XXBAC-BCX403H19.4; LAIR-1; MLAIR-1; CD305
  • Uniprot ID
    Q6GTX8
  • Gene Name
    LAIR1; CD305
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human LAIR1 (AAF71275.2) (Met1-Tyr165) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human LAIR1 consists of 155 amino acids and predicts a molecular mass of 17.2 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Human LAIR1 Protein (His Tag)

    Human LAIR1 Protein (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"