Human LAIR-1 / CD305 (Fc Tag) recombinant protein

Human LAIR-1 / CD305 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Leukocyte associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and are able to spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells, but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells. 

Leukocyte-associated immunoglobulin-like receptor 1

D7BWG0421E; 5133400O11RIK; BB115266; XXBAC-BCX403H19.4; LAIR-1; MLAIR-1; CD305

Q6GTX8

LAIR1; CD305

Human Cells

A DNA sequence encoding the human LAIR1 (Q6GTX8.1) (Met1-Tyr165) was expressed with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human LAIR1 consists 385 amino acids and predicts a molecular mass of 42.8 kDa.

> (86.1+10.4) % as determined by SDS-PAGE.