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Product Name
Mouse Junctional Adhesion Molecule A (Fc Tag) recombinant protein
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Description
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus (By similarity).
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Protein name
Junctional adhesion molecule A
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Protein short names
LY106; CD321; ESTM33; JAM-1; F11R; JAM-A; KAT; JAM1; AA638916; JCAM1; PAM-1; 9130004G24; JAMA; JCAM; JAM
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Uniprot ID
O88792
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Gene Name
F11r; Jam1; Jcam; Jcam1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse F11R (NP_766235.1) extracellular domain (Met 1-Ala 242) was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse F11R/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 457 amino acids and has a predicted molecular mass of 50.2 kDa. rmF11R/Fc monomer migrates as an is approximately 57 kDa band in SDS-PAGE under reducing conditions, with ~10% free Fc fragment.
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Purity
> 94 % as determined by SDS-PAGE
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Validations
Mouse JAM-A / F11R Protein (Fc Tag) SDS-PAGE
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