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Product Name
Human F11R/JAM1/JCAM/UNQ264/PRO301 (His tag) recombinant protein
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Description
Junctional Adhesion Molecule A (JAM-A) is a single-pass type I membrane protein that belongs to the immunoglobulin superfamily. JAM-A contains 2 Ig-like V-type (immunoglobulin-like) domains and Interacts with the ninth PDZ domain. JAM-A is localized to the tight junctions of both epithelial and endothelial cells. JAM-A seems to be involved in epithelial tight junction formation. JAM-A appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM-A, thereby preventing tight junction assembly. JAM-A plays a role in regulating monocyte transmigration involved in regulating integrity of the epithelial barrier. In the case of orthoreovirus infection, JAM-A serves as receptor for the virus.
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Protein name
F11 receptor(F11R)
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Protein short names
JAM1; JCAM; UNQ264; PRO301
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Uniprot ID
Q9Y624
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human F11R/JAM1/JCAM/UNQ264/PRO301 Ser28-Val238 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human F11R/JAM1/JCAM/UNQ264/PRO301 (His tag) recombinant protein
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