Rhesus IL-6 recombinant protein

Rhesus IL-6 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

Interleukin-6

HGF; BSF2; IFNB2; IL-6; IL6; HSF

F7FS80

IL6

E. coli

A DNA sequence encoding the the rhesus IL6 (NP_001036198.2 ) (Pro29-Met212) was expressed and purified.

Rhesus

The recombinant rhesus IL6 consists of 185 amino acids and has a calculated molecular mass of 21 kDa.

> 85 % as determined by SDS-PAGE

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
The ED₅₀ for this effect is typically 0.3-1.5 ng/mL.