Rhesus IL-6 recombinant protein

Cat.#: 500404

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Product Information

  • Product Name
    Rhesus IL-6 recombinant protein
  • Documents
  • Description
    Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
  • Protein name
    Interleukin-6
  • Protein short names
    HGF; BSF2; IFNB2; IL-6; IL6; HSF
  • Uniprot ID
    F7FS80
  • Gene Name
    IL6
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the the rhesus IL6 (NP_001036198.2 ) (Pro29-Met212) was expressed and purified.
  • Protein Species
    Rhesus
  • Molecular weight
    The recombinant rhesus IL6 consists of 185 amino acids and has a calculated molecular mass of 21 kDa.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Activity
    Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
    The ED50 for this effect is typically 0.3-1.5 ng/mL.
  • Validations

    Cynomolgus / Rhesus IL6 / Interleukin-6 Protein SDS-PAGE

    Cynomolgus / Rhesus IL6 / Interleukin-6 Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"