Anti-IL-6 antibody

Cat.#: 100843

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Product Information

  • Product Name
    Anti-IL-6 antibody
  • Documents
  • Description
    Rabbit polyclonal to IL-6
  • Tested applications
    ELISA, IHC-P
  • Species reactivity
    Cynomolgus IL6 / Interleukin-6
  • Alternative names
    HGF antibody; HSF antibody; BSF2 antibody; IL-6 antibody; IFNB2 antibody; Il-6 antibody; BSF2 antibody; HGF antibody; HSF antibody; IFNB2 antibody; IL6 antibody; IL-6 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Cynomolgus IL6 / Interleukin-6 (Pro29-Met212). IL6 / Interleukin-6 specific IgG was purified by Cynomolgus IL6 / Interleukin-6 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Cynomolgus IL6 / Interleukin-6. The detection limit for Cynomolgus IL6 / Interleukin-6 is approximately < 0.039 ng/well.

    IHC-P: 0.1-1 μg/mL

  • Validations

    IL6 / Interleukin-6 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    IL6 / Interleukin-6 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of cynomolgus IL6 in human spleen with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).

    IL6 / Interleukin-6 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    IL6 / Interleukin-6 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of cynomolgus IL6 in human tonsil with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).

    IL6 / Interleukin-6 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    IL6 / Interleukin-6 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of cynomolgus IL6 in human liver with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).

  • Background
    Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
  • References
    • Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.
    • Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24.
    • Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"