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Product Name
Human TFAM Recombinant protein (GST tag)
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Description
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. {PubMed:1737790, PubMed:19304746, PubMed:20410300, PubMed:22037171, PubMed:22037172, PubMed:22841477}.
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Protein name
Transcription factor A, mitochondrial
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Protein short names
TCF6; TCF6L2
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Uniprot ID
Q00059
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Gene Name
TFAM; TCF6; TCF6L2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
50-118 aa encoded by NM_003201 was inserted into PGEX-4T vector
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human TFAM SDS-PAGE
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