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Product Name
Human IL18/IGIF/IL1F4 recombinant protein
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Description
Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.
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Protein name
interleukin 18(IL18)
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Protein short names
IGIF; IL1F4
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Uniprot ID
Q14116
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human IL18/IGIF/IL1F4 Tyr37-Asp193 is expressed.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human IL18/IGIF/IL1F4 recombinant protein
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