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Product Name
Anti-IL-18 Rabbit antibody
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Description
IL-18 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, FC
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Species reactivity
Human
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Alternative names
IGIF; IL-18; IL-1g; IL1F4 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human IL18
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IHC: 1/200
FC: 1/20
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Validations
Western blot detection of IL18 in Hela cell lysates using IL18 Rabbit pAb(1:1000 diluted).Predicted band size:22kDa.Observed band size:17kDa.
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Background
Swiss-Prot Acc.Q14116.A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"