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Product Name
Human IGF2BP3 Recombinant protein (His tag)
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Description
RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {PubMed:16541107, PubMed:23640942}.
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Protein name
Insulin-like growth factor 2 mRNA-binding protein 3
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Protein short names
IMP3; KOC1; VICKZ3
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Uniprot ID
O00425
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Gene Name
IGF2BP3; IMP3; KOC1; VICKZ3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human IGF2BP3 (XP_047275738.1) 295-634 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human IGF2BP3 SDS-PAGE
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